Safety Considerations

Although Panhematin^® has few side effects, it does act as a mild anticoagulant. Thus, concurrent use of other anticoagulants such as heparin or Coumadin^® (warfarin) should be avoided. Panhematin^® may also produce superficial thrombophlebitis, especially if infused into a small vein. Panhematin^® is less likely to produce phlebitis if it is mixed with human albumin before it is given. Before Panhematin^® is used, it should be clear that the patient indeed suffers from one of the acute porphyrias (AIP, HCP, VP, ADP) and that the patient's symptoms are due to an acute attack. Panhematin^® therapy may not be indicated unless the diagnosis of acute porphyria is proven by a marked increase in urine PBG.