Porphyria Types

Hereditary Coproporphyria (HCP)

This is an autosomal dominant form of hepatic porphyria that is similar to AIP, except that some patients develop skin photosensitivity. The deficient enzyme is coproporphyrinogen oxidase. The diagnosis is established by finding excess coproporphyrin (especially coproporphyrin type III) in urine and stool. Other types of porphyrins show little or no increase. Urinary ALA and PBG are increased during acute attacks but may become normal on recovery. Reliable assays for the deficient enzyme are not generally available. If the enzyme is measured, red blood cells should not be used. The enzyme is found in mitochondria which are not present in red blood cells. Precautions and treatment for acute attacks are as described for AIP.

For more information please see AIP, HCP, VP, & ADP.

The APF is not responsible for the interpretive translations in other languages.

The information contained on the American Porphyria Foundation (APF) Web site or in the APF newsletter is provided for your general information only.

The APF does not give medical advice or engage in the practice of medicine. The APF under no circumstances recommends particular treatments for specific individuals, and in all cases recommends that you consult your physician or local treatment center before pursuing any course of treatment.

All information and content on this Web site are protected by copyright. All rights are reserved. Users are prohibited from modifying, copying, distributing, transmitting, displaying, publishing, selling, licensing, creating derivative works, or using any information available on or through the site for commercial or public purposes.

The American Porphyria Foundation (APF) Tax Forms 990 are readily available to the public. If you would like a copy, please contact the APF: 4900 Woodway, Suite 780, Houston, TX 77056. Toll free: 1.866.APF.3635.

Join the APF—Your donations help support patient and physician education as well as porphyria research. Learn more...