Dr. Micheline Mathews-Roth has been a member of the APF Scientific Advisory Board since its inception in 1982. She is a physician at Brigham & Women's Hospital, and Associate Professor of Medicine at Harvard Medical School, where she performs basic science and clinical research in photobiology.
Her clinical studies focus on developing photo-protective treatments for erythropoietic protoporphyria (EPP) and other human photosensitivity diseases. She has studied beta-carotene and the amino acid, cysteine, as protective agents against the effects of light in EPP patients. She is also developing gene therapy treatments for EPP.
Her basic science studies focus on: molecular biology of EPP and related gene therapy studies; carotenoid molecule photoprotective functions in the bacteria that contain carotenoids, as well as mammilian cells supplemented with them; genetics of the pigment formation in non-photosynthetic carotenoid-containing bacteria.
In addition to her work with the APF, Dr. Mathews-Roth founded and directs the Erythropoietic Protoporphyria Research and Education Fund (EPPREF), a support group for EPP patients and their families.
Dr. Mathews-Roth has made herself available to patients and physicians, offering advice about the light-sensitive porphyrias and the medical uses of beta-carotene and other carotenoid pigments. She has earned the accolades of people struggling with EPP around the world. Her unfailing generosity has long been a source of comfort to newly diagnosed patients who have turned to her for guidance in managing their disease.